Study on acetylcholinesterase inhibition induced by endogenous neurotoxin with an enzyme-semiconductor photoelectrochemical system

Chem Commun (Camb). 2009 May 21:(19):2682-4. doi: 10.1039/b900623k. Epub 2009 Mar 26.

Abstract

The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin.

MeSH terms

  • Acetylcholinesterase / drug effects*
  • Acetylcholinesterase / metabolism
  • Biosensing Techniques / methods
  • Cholinesterase Inhibitors / chemistry*
  • Gold
  • Isoquinolines / pharmacology*
  • Kinetics
  • Nanotubes
  • Neurotoxins / pharmacology*
  • Photochemistry
  • Semiconductors
  • Titanium

Substances

  • Cholinesterase Inhibitors
  • Isoquinolines
  • N-methylsalsolinium
  • Neurotoxins
  • titanium dioxide
  • Gold
  • Titanium
  • Acetylcholinesterase