Influence of antenatal care, placental weight and genetic variation on low birth weight, Makassar Indonesia

Asia Pac J Public Health. 2008 Oct:20 Suppl:15-7.


Inadequate antenatal care and nutrition, gene variation (CYP2A6), and poor placental growth are associated with low birthweight (LBW). The objective for this study was to analyze risk factors for LBW, including antenatal care, gene variation CYP2A6 and placental weight. A case control of infants with a birthweight less than 2500 gm, compared to a control group of infants with a birthweight > 2500 gm. There were 57 cases and a similar number of controls. In the analysis odds ratios (OR) were calculated for each risk factor. Low placental weight was strongly related to low birth weight (OR 43.9 CI 14.7-129.8). Mothers who had inadequate antenatal care had increased risk of LBW (OR 2.7, 95% CI. 1.2-6.1). The gene variation CYP2A6 was found to be risk factor for a lighter placenta weight (OR 9.5 95% CI. 4.0-22.3). Programs to improve antenatal care and monitoring for the gene variation CYP2A6 would reduce the incidence of LBW.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Case-Control Studies
  • Cytochrome P-450 CYP2A6
  • Female
  • Genetic Variation
  • Humans
  • Indonesia
  • Infant, Low Birth Weight*
  • Infant, Newborn
  • Organ Size
  • Placenta / anatomy & histology*
  • Placentation / physiology
  • Pregnancy
  • Prenatal Care*
  • Prenatal Nutritional Physiological Phenomena
  • Risk Factors


  • Aryl Hydrocarbon Hydroxylases
  • CYP2A6 protein, human
  • Cytochrome P-450 CYP2A6