Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis

J Infect Dis. 2009 Aug 1;200(3):448-52. doi: 10.1086/600072.


Interleukin (IL)-10 directly inhibits human immunodeficiency virus type 1 (HIV-1) replication, but it may also promote viral persistence by inactivation of effector immune mechanisms. Here, we show in an African cohort that individuals with genotypes associated with high IL-10 production at 2 promoter single-nucleotide polymorphisms (-1082 and -592) were less likely to become HIV-1 infected but had significantly higher median plasma viral loads during the acute phase (<or=3 months after infection). However, as the infection progressed, the association between genotype and median viral load was reversed. Thus, IL-10 may influence HIV-1 susceptibility and pathogenesis, but effects on the latter may differ according to the infection phase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • HIV Infections / epidemiology
  • HIV Infections / genetics*
  • HIV-1* / genetics
  • HIV-1* / immunology
  • Humans
  • Interleukin-10 / genetics*
  • Longitudinal Studies
  • Mutation
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic / genetics*
  • South Africa / epidemiology
  • Viral Load


  • Interleukin-10