[Can tumor necrosis factor inhibitors induce sclero-uveitis?]

J Fr Ophtalmol. 2009 Sep;32(7):511.e1-6. doi: 10.1016/j.jfo.2009.04.029. Epub 2009 Jun 16.
[Article in French]


We report three cases of female patients who presented a first episode of unilateral scleritis or acute anterior uveitis while they were treated for 12-16 months by TNF inhibitor: etanercept (Enbrel((R))) 25mg twice weekly for rheumatologic diseases (rheumatoid arthritis or ankylosing spondylitis). Ocular inflammation was resistant to the usual treatment. Some cases of scleritis and uveitis are known to be drug-induced. TNF inhibitors seem to be part of them. Ocular inflammation is usually the first episode. It appears generally in the first year of the treatment by TNF inhibitors and resists to usual treatment. The general disease is usually well stabilized. In our cases, inflammation decreased only when the etanercept was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antirheumatic Agents / adverse effects*
  • Etanercept
  • Female
  • Humans
  • Immunoglobulin G / adverse effects*
  • Middle Aged
  • Receptors, Tumor Necrosis Factor
  • Scleritis / chemically induced*
  • Tumor Necrosis Factor Inhibitors*
  • Uveitis / chemically induced*


  • Antirheumatic Agents
  • Immunoglobulin G
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor Inhibitors
  • Etanercept