An investigation of the risk factors for infection with methicillin-resistant Staphylococcus aureus among patients in a neonatal intensive care unit

Am J Infect Control. 2009 Sep;37(7):580-6. doi: 10.1016/j.ajic.2009.02.008. Epub 2009 Jun 17.


Background: The aims of this study were to investigate the risk factors of methicillin-resistant Staphylococcus aureus (MRSA) infection among infants to establish effective infection control measures for neonatal intensive care unit (NICU).

Methods: Data were prospectively collected from 961 infants hospitalized in a teaching hospital in Japan, from July 2002 through December 2005.

Results: Among all infants, 28 (2.9%) developed MRSA infections. Multivariate logistic regression analyses demonstrated the risk factors for developing MRSA infections to include a low birth weight (odds ratio [OR], 0.91; 95% confidence interval [CI]: 0.93-0.99), the presence of eye mucous (OR, 6.78; 95% CI: 2.87-16.01), the practice of kangaroo mother care (OR, 3.82; 95% CI: 1.11-13.13), and the MRSA colonization rate (OR, 11.12; 95% CI: 1.32-93.89).

Conclusion: The risk factors for developing a MRSA infection among infants in NICU were a low birth weight, the presence of eye mucous, the practice of kangaroo mother care, and a high MRSA colonization rate. Therefore, extra attention should be given to infants in high-risk groups demonstrating a low birth weight and the presence of eye mucous and who have undergone kangaroo mother care. As a result, the cohort isolation of infants with MRSA may therefore be an effective strategy to prevent MRSA infections.

MeSH terms

  • Birth Weight / immunology
  • Birth Weight / physiology
  • Carrier State / microbiology
  • Carrier State / prevention & control
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Cross Infection / prevention & control
  • Disease Susceptibility
  • Female
  • Hospitals, Teaching
  • Humans
  • Infant Care / methods
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infection Control
  • Intensive Care Units, Neonatal / statistics & numerical data*
  • Japan / epidemiology
  • Logistic Models
  • Male
  • Methicillin-Resistant Staphylococcus aureus*
  • Multivariate Analysis
  • Odds Ratio
  • Prospective Studies
  • Risk Factors
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / prevention & control