Variation in genomic recombination rates among heterogeneous stock mice

Genetics. 2009 Aug;182(4):1345-9. doi: 10.1534/genetics.109.105114. Epub 2009 Jun 17.


We used a large panel of pedigreed, genetically admixed house mice to study patterns of recombination rate variation in a leading mammalian model system. We found considerable inter-individual differences in genomic recombination rates and documented a significant heritable component to this variation. These findings point to clear variation in recombination rate among common laboratory strains, a result that carries important implications for genetic analysis in the house mouse.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Genome
  • Kinetics
  • Mice / genetics*
  • Recombination, Genetic*