Novel Mi-2 related ATP-dependent chromatin remodelers

Abstract

Distinct chromatin remodeling complexes can share a common ATPase subunit. The functional characteristics of each remodeling complex are determined by the respective ATPase-associated subunits. The Mi-2 nucleosome remodeling ATPase has so far only been shown to reside within Nucleosome Remodeling and Deacetylase (NuRD) complexes. Here we will review the recent discovery of two Mi-2 related remodelers that function independently of NuRD and that act as SUMO (small ubiquitin-related modifier)-dependent corepressors: First, Mi-2 exists in a novel chromatin remodeling complex, dMec, that does not rely on histone deacetylation to effect transcriptional repression of proneural genes. Second, the Mi-2 related factor dCHD3 acts as a monomer and does not associate with additional subunits in vivo. These recent results have uncovered an unanticipated complexity in the composition and function of CHD (Chromodomain-Helicase-DNA-binding) complexes.