The cell cycle and acute kidney injury

Kidney Int. 2009 Sep;76(6):604-13. doi: 10.1038/ki.2009.224. Epub 2009 Jun 17.


Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used to control and perhaps to prevent acute kidney injury. This review is written to address the correlation between cellular life and death in kidney tubules, especially in acute kidney injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Apoptosis
  • Cell Cycle*
  • Cyclin-Dependent Kinase Inhibitor p21 / physiology
  • Cyclin-Dependent Kinase Inhibitor p27 / physiology
  • Cyclin-Dependent Kinases / physiology
  • DNA Damage
  • Humans
  • Kidney / pathology*


  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases