Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism

Osteoporos Int. 2010 Apr;21(4):597-607. doi: 10.1007/s00198-009-0985-z. Epub 2009 Jun 18.


During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation.

Introduction: To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints.

Methods: Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest.

Results: Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (-1.8(0.9)%, p = 0.042) whereas the RVE group did not (-0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12).

Conclusions: The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon / methods
  • Adult
  • Bed Rest / adverse effects*
  • Biomarkers / blood
  • Biomarkers / urine
  • Body Composition
  • Bone Density / physiology
  • Bone Resorption / etiology
  • Bone Resorption / physiopathology
  • Bone Resorption / prevention & control*
  • Bone and Bones / metabolism
  • Calcium / blood
  • Calcium / urine
  • Follow-Up Studies
  • Humans
  • Male
  • Muscular Atrophy / etiology
  • Muscular Atrophy / prevention & control*
  • Resistance Training / methods*
  • Vibration / therapeutic use*


  • Biomarkers
  • Calcium