In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

Mycoses. 2010 Nov;53(6):495-9. doi: 10.1111/j.1439-0507.2009.01747.x.


Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml(-1) respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Candida / drug effects*
  • Drug Synergism
  • Fungal Proteins / antagonists & inhibitors
  • Metergoline / pharmacology*
  • Microbial Sensitivity Tests
  • Microbial Viability / drug effects
  • Phospholipases / antagonists & inhibitors


  • Antifungal Agents
  • Fungal Proteins
  • Metergoline
  • Amphotericin B
  • Phospholipases