Remyelination - An Effective Means of Neuroprotection

Horm Behav. 2010 Jan;57(1):56-62. doi: 10.1016/j.yhbeh.2009.06.004. Epub 2009 Jun 16.

Abstract

Remyelination following central nervous system (CNS) demyelination restores rapid saltatory conduction of action potentials and contributes to the maintenance of axonal integrity. This robust regenerative phenomenon stands in contrast to the limited repair capacity that is characteristic of CNS neuronal injury. However, despite its efficiency in experimental models and some clinical diseases, remyelination failure becomes an increasingly pronounced feature of the pathology of chronic multiple sclerosis (MS) lesions. Chronic demyelination predisposes axons to atrophy, an irreversible event that is a major pathological correlate of progressive functional decline. This has created a compelling case for developing therapies that promote remyelination: evidence from experimental animal models suggests that hormones may have a beneficial role to play in this regard.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / cytology
  • Adult Stem Cells / physiology
  • Animals
  • Central Nervous System / cytology
  • Central Nervous System / physiology*
  • Hormones / therapeutic use*
  • Humans
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / physiopathology*
  • Myelin Sheath / physiology*
  • Oligodendroglia / cytology
  • Oligodendroglia / physiology
  • Regeneration / physiology*

Substances

  • Hormones