Treatment of newly diagnosed diabetic cats with glargine insulin improves glycaemic control and results in higher probability of remission than protamine zinc and lente insulins

J Feline Med Surg. 2009 Aug;11(8):683-91. doi: 10.1016/j.jfms.2009.05.016. Epub 2009 Jun 18.


Glycaemic control and remission probabilities were compared in 24 newly diagnosed diabetic cats treated twice daily with either glargine, protamine zinc (PZI) or lente insulin and fed a low carbohydrate diet. After day 17, the probability of remission was substantially higher for cats with lower mean 12h blood glucose concentrations on day 17, irrespective of insulin type. Glargine-treated cats had lower mean 12h blood glucose concentrations on day 17 than PZI- or lente-treated cats, and all eight glargine-treated cats achieved remission compared to three PZI- and two lente-treated cats. The probability of remission was greater for cats treated with glargine than cats treated with PZI or lente insulin. In newly diagnosed diabetic cats, twice daily treatment with glargine provides better glycaemic control and higher probability of remission compared to twice daily treatment with PZI or lente insulin. Good glycaemic control soon after diagnosis is associated with increased probability of remission and should be the goal of insulin therapy.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Blood Glucose
  • Cat Diseases / blood
  • Cat Diseases / diet therapy
  • Cat Diseases / drug therapy*
  • Cats
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / diet therapy
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / veterinary*
  • Dietary Carbohydrates / administration & dosage
  • Female
  • Hypoglycemic Agents / administration & dosage*
  • Insulin / administration & dosage
  • Insulin / analogs & derivatives*
  • Insulin Glargine
  • Insulin, Long-Acting / administration & dosage*
  • Male
  • Protamines / administration & dosage*
  • Remission Induction / methods
  • Treatment Outcome


  • Blood Glucose
  • Dietary Carbohydrates
  • Hypoglycemic Agents
  • Insulin
  • Insulin, Long-Acting
  • Protamines
  • protamine zinc
  • Insulin Glargine