Women's reproductive related disorders (RRDs)

J Affect Disord. 2010 Apr;122(1-2):10-3. doi: 10.1016/j.jad.2009.05.018. Epub 2009 Jun 21.


Background: In some but not all women, periods of hormonal change may be associated with diversified physical, mental and cognitive symptoms that may be severe enough to warrant treatment. These reproductive-life periods include pregnancy, post-partum, the premenstrual and perimenopausal periods.

Conclusions: Disorders during these periods are quite prevalent and may be grouped together as Reproductive Related Disorders (RRDs). They are characterized by their timing, epidemiologic associations and shared vulnerabilities, but not necessarily by their descriptive phenomenology that often times is diversified among women but consistent within each individual woman. The pathophysiology of RRDs is suggested to be maladaptation of vulnerable women to normal hormonal changes. As such, RRDs provide for an interdisciplinary diagnostic model of mostly-affective disorders that differ from the current descriptive-based entities.

Clinical relevance: Treatment options may be aimed at the trigger-the hormonal changes or instability; or may be symptomatic-in cases of depression or anxiety they are mostly SSRIs.

Publication types

  • Review

MeSH terms

  • Brain / physiopathology
  • Climacteric / physiology
  • Climacteric / psychology*
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / epidemiology
  • Cognition Disorders / physiopathology
  • Cognition Disorders / psychology
  • Cross-Sectional Studies
  • Depression, Postpartum / diagnosis*
  • Depression, Postpartum / epidemiology
  • Depression, Postpartum / physiopathology
  • Depression, Postpartum / psychology
  • Female
  • Gonadal Steroid Hormones / blood
  • Humans
  • Mental Disorders / diagnosis*
  • Mental Disorders / epidemiology
  • Mental Disorders / physiopathology
  • Mental Disorders / psychology
  • Mood Disorders / diagnosis
  • Mood Disorders / epidemiology
  • Mood Disorders / physiopathology
  • Mood Disorders / psychology
  • Patient Care Team
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / epidemiology
  • Pregnancy Complications / physiopathology
  • Pregnancy Complications / psychology
  • Risk Factors


  • Gonadal Steroid Hormones