Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening

Hendra Gunosewoyo; Mark J Coster; Maxwell R Bennett; Michael Kassiou

doi:10.1016/j.bmc.2009.05.083

Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening

Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. doi: 10.1016/j.bmc.2009.05.083. Epub 2009 Jun 12.

Authors

Hendra Gunosewoyo¹, Mark J Coster, Maxwell R Bennett, Michael Kassiou

Affiliation

¹ School of Chemistry, University of Sydney, NSW 2006, Australia.

PMID: 19540765
DOI: 10.1016/j.bmc.2009.05.083

Abstract

The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzamides / chemistry
Benzamides / pharmacology*
Binding Sites
Biological Products / chemistry
Biological Products / pharmacology*
Drug Evaluation, Preclinical
Guanidines / chemistry
Guanidines / pharmacology*
Humans
Hydrazines / chemistry
Hydrazines / pharmacology*
Molecular Structure
Protein Binding
Purinergic P2 Receptor Antagonists*
Receptors, Purinergic P2 / analysis
Receptors, Purinergic P2 / metabolism
Triazoles / chemistry
Triazoles / pharmacology*

Substances

Benzamides
Biological Products
Guanidines
Hydrazines
Purinergic P2 Receptor Antagonists
Receptors, Purinergic P2
Triazoles
dicyandiamido