Effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients

J Ren Nutr. 2009 Nov;19(6):475-8. doi: 10.1053/j.jrn.2009.04.005. Epub 2009 Jun 21.


Objective: We examined the effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients.

Design: This was a randomized, double-blinded, placebo-controlled clinical trial.

Setting: This study was conducted at the Shahid Faghihi and Namazi Dialysis Centers in Shiraz, Iran.

Patients: Fifty-five hemodialysis patients (32 men and 23 women) participated after meeting the following criteria: zinc deficiency, treated for a minimum of 6 months; no record of hospitalizations in the preceding 3 months; and hemodialysis treatment 2 to 3 times per week.

Intervention: Patients were randomly divided into two groups. The zinc supplementation group (n=28) received a 220-mg zinc sulfate capsule, and the control group (n=27) received a placebo capsule (220 mg corn starch), for 42 days.

Main outcome measures: Fasting, predialysis serum samples were collected on days 0 and 42 to determine serum zinc and C-reactive protein levels.

Results: After supplementation, subjects in the zinc-supplemented group showed significant increases in serum zinc concentrations, from 57.4+/-2.4 microg/dL SEM on day 0 to 88.4+/-4.8 microg/dL SEM on day 42. Serum C-reactive protein concentrations were initially high among subjects in the control (15.1+/-3.9 mg/L SEM) and zinc-supplemented (13.5+/-3.8 mg/L SEM) groups. Serum C-reactive protein concentrations in the control group increased throughout the study period, but did not reach statistical significance. A progressive decrease in serum C-reactive protein concentrations was observed in the zinc-supplemented group from the beginning (13.5+/-3.8mg/L SEM) to the end (10.5+/-3.5mg/L SEM) of the study, but this event was not significant.

Conclusion: Zinc supplementation intake may cause an increase in serum zinc concentrations, leading to a decrease of inflammation in hemodialysis patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Astringents / administration & dosage
  • Astringents / therapeutic use
  • C-Reactive Protein / metabolism*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Renal Dialysis*
  • Zinc / blood*
  • Zinc / deficiency
  • Zinc Sulfate / administration & dosage
  • Zinc Sulfate / therapeutic use*


  • Astringents
  • Zinc Sulfate
  • C-Reactive Protein
  • Zinc