Challenges, current status and future perspectives of proteomics in improving understanding, diagnosis and treatment of vascular disease

Eur J Vasc Endovasc Surg. 2009 Sep;38(3):346-55. doi: 10.1016/j.ejvs.2009.05.008. Epub 2009 Jul 9.

Abstract

Technical advances have seen the rapid adoption of genomics and multiplex genetic polymorphism identification to research on vascular diseases. The utilization of proteomics for the study of vascular diseases has been limited by comparison. In this review we outline currently available proteomics techniques, the challenges to using these approaches and modifications which may improve the utilization of proteomics in the study of vascular diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / analysis
  • Electrophoresis, Gel, Two-Dimensional / trends
  • Electrophoresis, Polyacrylamide Gel / trends
  • Humans
  • Mass Spectrometry / trends
  • Predictive Value of Tests
  • Protein Array Analysis / trends
  • Proteins / analysis*
  • Proteomics / trends*
  • Reproducibility of Results
  • Vascular Diseases / diagnosis*
  • Vascular Diseases / therapy*

Substances

  • Biomarkers
  • Proteins