The effects of calcium dobesilate on the mechanical function of rat hearts

J Cardiovasc Surg (Torino). 2009 Jun;50(3):395-401.


Aim: Calcium dobesilate is an angio-protective agent that has positive effects on hemorheological parameters. It decreases blood and plasma viscosity, thrombocyte aggregation, and microvascular hyperpermeability. It is an antioxidant that increases endothelial-derived vasodilator substance secretion. In this experimental study, the effects of calcium dobesilate on myocardial ischemia reperfusion injury were investigated.

Methods: Using the Langendorff setup, 24 adult Wistar albino rat hearts were perfused. MeanP (mean pressure perfusing the coronary arteries), PSP (maximum left ventricle pressure), +dp/dt(max) (change in contraction power over time), -dp/dt(max) (change in relaxing power over time), PP (peak systolic pressure-minimum balloon pressure) and bpm (number of heart beats per minute) were evaluated. The control group (N.=6) was perfused with Tyrode solution alone. The other three groups (N.=6 for each group) were perfused with the Tyrode solution and calcium dobesilate either before ischemia, during the ischemia reperfusion period, or during the reperfusion-only period.

Results: The meanP values were significantly higher in groups perfused by calcium dobesilate. For other parameters, calcium dobesilate did not demonstrate a positive effect.

Conclusions: This study showed that calcium dobesilate may have cardio-protective effects in isolated, perfused rat hearts. In hearts perfused by calcium dobesilate, the increase in mean P may be explained by the increase in endothelium-derived vasodilator substances. Further studies are needed to better characterize the myocardial protective effects of calcium dobesilate.

MeSH terms

  • Animals
  • Calcium Dobesilate / pharmacology*
  • Cardiotonic Agents / pharmacology*
  • Coronary Circulation / drug effects
  • Coronary Vessels / drug effects*
  • Coronary Vessels / physiopathology
  • Disease Models, Animal
  • Female
  • Heart Rate / drug effects
  • Male
  • Myocardial Contraction / drug effects*
  • Myocardial Reperfusion Injury / physiopathology
  • Myocardial Reperfusion Injury / prevention & control*
  • Rats
  • Rats, Wistar
  • Time Factors
  • Vasodilation / drug effects
  • Ventricular Function, Left / drug effects*
  • Ventricular Pressure / drug effects


  • Cardiotonic Agents
  • Calcium Dobesilate