Acute fibrinous and organizing pneumonia following hematopoietic stem cell transplantation

Korean J Intern Med. 2009 Jun;24(2):156-9. doi: 10.3904/kjim.2009.24.2.156. Epub 2009 Jun 8.


A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure. Chest CT scans showed miliary nodules and patchy consolidations. Histological examination revealed numerous fibrin balls within the alveoli and thickening of the alveolar septum, both of which are typical pathological features of acute fibrinous and organizing pneumonia (AFOP). We report the first case of AFOP following allogeneic hematopoietic stem cell transplantation.

Keywords: Acute fibrinous; Graft-versus-host disease; Hematopoietic stem cell transplantation; organizing pneumonia.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents / therapeutic use
  • Biopsy
  • Cryptogenic Organizing Pneumonia / etiology
  • Cryptogenic Organizing Pneumonia / pathology
  • Fatal Outcome
  • Glucocorticoids / administration & dosage
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hemoptysis / etiology
  • Humans
  • Leukemia, Myeloid, Acute / surgery*
  • Lung Diseases / etiology*
  • Lung Diseases / pathology
  • Male
  • Middle Aged
  • Pleural Effusion / etiology
  • Pulse Therapy, Drug
  • Radiography, Thoracic
  • Respiratory Insufficiency / etiology
  • Tomography, X-Ray Computed


  • Anti-Bacterial Agents
  • Glucocorticoids