Specific biofunctional performances of the hydroxyapatite-sodium maleate copolymer hybrid coating nanostructures evaluated by in vitro studies

J Mater Sci Mater Med. 2009 Nov;20(11):2305-16. doi: 10.1007/s10856-009-3800-7. Epub 2009 Jun 20.


The nanohybrid structures consisting of hydroxyapatite (HA) and sodium maleate-vinyl acetate copolymer (MP) deposited by Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique on Ti surfaces were investigated for specific biological qualities required in bone implantology. The data from in vitro studies demonstrated that human primary osteoblasts (OBs) firmly adhered to Ti coated with HA-MP as indicated by cytoskeleton and vinculin dynamics. OBs spread onto biomaterial surface and formed groups of cells which during their biosynthetic activity expressed OB phenotype specific markers (collagen and non-collagenous proteins) and underwent controlled proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Bone and Bones / metabolism
  • Cell Adhesion
  • Cell Proliferation
  • Cells, Cultured
  • Coated Materials, Biocompatible / metabolism
  • Collagen / chemistry
  • Cytoskeleton / chemistry
  • Durapatite / chemistry*
  • Humans
  • Maleates / chemistry*
  • Mesenchymal Stem Cells / cytology
  • Microscopy, Fluorescence / methods
  • Nanocomposites
  • Nanostructures / chemistry*
  • Osteoblasts / metabolism
  • Phenotype
  • Polymers / chemistry*
  • Vinculin / chemistry


  • Biocompatible Materials
  • Coated Materials, Biocompatible
  • Maleates
  • Polymers
  • Vinculin
  • Collagen
  • Durapatite
  • maleic acid