The role of protein synthesis in cell cycling and cancer

Mol Oncol. 2009 Dec;3(5-6):402-8. doi: 10.1016/j.molonc.2009.05.003. Epub 2009 Jun 11.

Abstract

Cell cycling and protein synthesis are both key physiological tasks for cancer cells. Here we present a model for how the elongation phase of protein synthesis, governed by elongation factor 2 and elongation factor 2 kinase, both modulates and responds to cell cycling. Within this framework we also discuss survivin, a protein with both pro-mitotic and anti-apoptotic roles whose persistence in the cell is tied to protein synthesis due to its short half-life. Finally, we provide a brief overview of efforts of cancer researchers to target EF2 and EF2 kinase.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Cycle / physiology*
  • Cell Line, Tumor
  • Elongation Factor 2 Kinase / genetics
  • Elongation Factor 2 Kinase / metabolism
  • Humans
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / physiopathology
  • Peptide Elongation Factor 2 / genetics
  • Peptide Elongation Factor 2 / metabolism
  • Protein Biosynthesis*
  • Survivin

Substances

  • BIRC5 protein, human
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins
  • Peptide Elongation Factor 2
  • Survivin
  • Elongation Factor 2 Kinase