Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application

J Card Surg. Jan-Feb 2010;25(1):127-34. doi: 10.1111/j.1540-8191.2009.00820.x. Epub 2009 Jun 22.


Remote ischemic conditioning is a novel concept of protection against ischemia-reperfusion injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a powerful systemic protection against prolonged ischemia in a distant organ. This conditioning phenomenon is clinically applicable and can be performed before--preconditioning, during--perconditioning, or after--postconditioning prolonged distant organ ischemia. The remote ischemic conditioning may have an immense impact on clinical practice in the near future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Coronary Circulation*
  • Hemodynamics*
  • Humans
  • Ischemia
  • Ischemic Preconditioning, Myocardial / methods*
  • Myocardial Reperfusion Injury / prevention & control*
  • Signal Transduction
  • Time Factors