Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers

Nat Rev Cancer. 2009 Jul;9(7):476-88. doi: 10.1038/nrc2674.


Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / therapeutic use*
  • Budesonide / therapeutic use
  • Clinical Trials as Topic
  • Cysteine / analogs & derivatives
  • Cysteine / therapeutic use
  • Humans
  • Inositol / therapeutic use
  • Lung Neoplasms / etiology
  • Lung Neoplasms / prevention & control*
  • Smoking / adverse effects*
  • Thiocarbamates / therapeutic use


  • Anticarcinogenic Agents
  • N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine
  • Thiocarbamates
  • Inositol
  • Budesonide
  • Cysteine