Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial

Gastroenterology. 1991 Dec;101(6):1564-70. doi: 10.1016/0016-5085(91)90393-y.


To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. A motility catheter with recording sites in the antrum and duodenum was placed on the first day of the study and remained in place until the end of the 5-day study. Cisapride (0.3 mg/kg PO t.i.d.) or placebo was given in double-blind randomized crossover fashion, with a 2-day "washout" interval. Antroduodenal motility was recorded on days 2 and 5. Recording consisted of 4 hours of fasting and 2 hours after a complex liquid meal labeled with 99mTc. Gastric emptying was assessed for 1 hour after the meal. Based on manometry, 16 patients had neuropathic and 4 patients had myopathic disorders. Cisapride had no effect on the discrete, qualitative abnormalities found in individual records. Cisapride increased the postprandial duodenal motility index from 1180 +/- 256 mm Hg/30 min after placebo to 2385 +/- 430 mm Hg/30 min (P less than 0.05) but had no significant effect on the antral motility index. Cisapride did not alter the profound delay in gastric emptying; time to reach 50% of initial activity (T1/2) was 105 +/- 20 vs. 93 +/- 19 minutes and percentage of retention after 60 minutes (R60) 56% +/- 4% vs. 58% +/- 4% in control vs. cisapride, respectively. In summary, in children with chronic intestinal pseudoobstruction, cisapride increased postprandial duodenal motility but did not improve gastric emptying.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Child, Preschool
  • Cisapride
  • Double-Blind Method
  • Duodenum / drug effects
  • Duodenum / physiopathology
  • Eating / physiology
  • Female
  • Gastric Emptying / drug effects
  • Gastrointestinal Motility / drug effects*
  • Humans
  • Infant
  • Intestinal Pseudo-Obstruction / blood
  • Intestinal Pseudo-Obstruction / drug therapy*
  • Intestinal Pseudo-Obstruction / physiopathology
  • Male
  • Manometry
  • Piperidines / blood
  • Piperidines / pharmacology*
  • Piperidines / therapeutic use
  • Serotonin Antagonists / blood
  • Serotonin Antagonists / pharmacology*
  • Serotonin Antagonists / therapeutic use


  • Piperidines
  • Serotonin Antagonists
  • Cisapride