Neuropsychiatric sequelae of traumatic brain injury

Semin Neurol. 2009 Jul;29(3):247-55. doi: 10.1055/s-0029-1223878. Epub 2009 Jun 23.


The prevalence of traumatic brain injury (TBI) is increasing, particularly in the population of veterans. Many times, the motor and sensory consequences of TBI are addressed, but the post-TBI neuropsychiatric sequelae, which may be as, or even more devastating than the motor and sensory deficits, are left unattended. Cognitive, mood, anxiety, thought, impulse, and substance disorders, and a variety of personality disorders can be seen following TBI. The neuropsychiatric sequelae of TBI not only interfere with day-to-day function, but can severely impede rehabilitation efforts. To date, there have been few large-scale studies looking at the effectiveness of the various treatment modalities, including psychotherapeutic and pharmacological interventions.

MeSH terms

  • Brain Injuries / complications*
  • Brain Injuries / pathology
  • Consciousness / physiology
  • Disease Progression
  • Humans
  • Mental Disorders / classification
  • Mental Disorders / etiology*
  • Mental Disorders / therapy
  • Motivation