Pd(PPh3)4-PEG 400 catalyzed protocol for the atom-efficient Stille cross-coupling reaction of organotin with aryl bromides

Wen-Jun Zhou; Ke-Hu Wang; Jin-Xian Wang

doi:10.1021/jo9005206

Pd(PPh3)4-PEG 400 catalyzed protocol for the atom-efficient Stille cross-coupling reaction of organotin with aryl bromides

J Org Chem. 2009 Aug 7;74(15):5599-602. doi: 10.1021/jo9005206.

Authors

Wen-Jun Zhou¹, Ke-Hu Wang, Jin-Xian Wang

Affiliation

¹ Institute of Chemistry, Department of Chemistry, Northwest Normal University, 967 An Ning Road (E.), Lanzhou 730070, P. R. China.

PMID: 19552378
DOI: 10.1021/jo9005206

Abstract

Aryl bromides (4 equiv) were coupled efficiently with organotin (1 equiv) in an atom-efficient way using the tetra(triphenylphosphine)palladium/polyethylene glycol 400 (Pd(PPh3)4/PEG 400) catalytic system in the presence of sodium acetate (NaOAc) as base at 100 degrees C, providing excellent yields of the corresponding functionalized biaryls in short reaction times.