Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study

Aliment Pharmacol Ther. 2009 Sep 15;30(6):643-51. doi: 10.1111/j.1365-2036.2009.04074.x. Epub 2009 Jun 23.

Abstract

Background: No previous study has examined the comorbidity of Irritable Bowel Syndrome (IBS) and Generalized Anxiety Disorder (GAD) in a general population using standardized diagnostic methods.

Aim: To examine the prevalence, comorbidity and risk correlates of IBS and GAD in a general population.

Methods: A random community-based telephone survey was conducted. The questionnaire covered symptoms of IBS, GAD, core depressive symptoms, help-seeking behaviour and functional impairment on the Sheehan Disability Scale.

Results: A total of 2005 participants completed the interview. The current prevalence of IBS was 5.4% and the 12-month prevalence of GAD was 4%. GAD was five times more common among IBS respondents than non-IBS respondents (OR: 5.84, P < 0.001), whereas IBS was 4.7 times more common among GAD respondents than among non-GAD respondents (OR: 6.32, P < 0.001). Core depressive symptoms (OR: 6.25, P < 0.01) and education level (OR: 5.918, P = 0.021) were risk correlates of GAD among IBS respondents. Comorbid respondents were more impaired than respondents having either disorder alone, but were not more likely to seek professional help than IBS-only respondents.

Conclusion: Irritable Bowel Syndrome and GAD comorbidity was common and added to impairment in the community. The strong association between psychiatric morbidity and IBS observed in referral centres was not a consequence of increased help-seeking behaviour.

MeSH terms

  • Adolescent
  • Adult
  • Comorbidity
  • Depressive Disorder / epidemiology*
  • Female
  • Humans
  • Irritable Bowel Syndrome / epidemiology*
  • Irritable Bowel Syndrome / psychology
  • Male
  • Middle Aged
  • Prevalence
  • Psychiatric Status Rating Scales
  • Risk Factors
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Young Adult