Synthetic lethality--a new direction in cancer-drug development

N Engl J Med. 2009 Jul 9;361(2):189-91. doi: 10.1056/NEJMe0903044. Epub 2009 Jun 24.
No abstract available

Publication types

  • Comment
  • Editorial

MeSH terms

  • DNA Damage
  • DNA Repair
  • Drug Design*
  • Drug Screening Assays, Antitumor
  • Genes, BRCA1*
  • Genes, BRCA2*
  • Genes, Lethal
  • Humans
  • Mutation
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Phthalazines / therapeutic use
  • Piperazines / therapeutic use
  • Poly(ADP-ribose) Polymerase Inhibitors*

Substances

  • Phthalazines
  • Piperazines
  • Poly(ADP-ribose) Polymerase Inhibitors
  • olaparib