Kindling the flame of integrin activation and function with kindlins

Curr Opin Hematol. 2009 Sep;16(5):323-8. doi: 10.1097/MOH.0b013e32832ea389.

Abstract

Purpose of review: There are three kindlin family members in vertebrates, which have high-sequence homology and a common organization signature with a C-terminal 4.1, ezrin, radixin, moesin (FERM) domain bisected by a pleckstrin-homology domain. Although the cell and tissue distributions of the three kindlins differ, there is a consistent and close interrelationship between kindlins and integrins, and alterations of kindlin expression affect integrin-dependent functions. However, in-vivo data on the functions of the kindlins and their mechanisms of action have been lacking.

Recent findings: Recent studies have shown that deficiencies of each of the three kindlins result in profound and distinct phenotypes, ranging from skin and intestinal defects (kindlin-1), embryonic lethality due to cardiac developmental problems (kindlin-2), to marked abnormalities in platelet, leukocyte and erythrocyte function (kindlin-3). A human disease characterized by bleeding, frequent infections and osteopetrosis has now been attributed to mutations in the gene encoding for kindlin-3. These defects are consistent with recent data showing that kindlins control integrin activation and function.

Summary: The three members of the kindlin family have now been implicated as essential regulators of integrin function in individual cells and in whole organisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cytoskeletal Proteins / deficiency
  • Cytoskeletal Proteins / physiology*
  • Humans
  • Integrins / genetics
  • Integrins / metabolism*
  • Integrins / physiology
  • Membrane Proteins / deficiency
  • Membrane Proteins / physiology
  • Neoplasm Proteins / deficiency
  • Neoplasm Proteins / physiology

Substances

  • Cytoskeletal Proteins
  • FERMT1 protein, human
  • Integrins
  • MIG2B protein, human
  • Membrane Proteins
  • Neoplasm Proteins
  • kindlin-3 protein, mouse