Development and pathology of pulmonary hypertension

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S3-S9. doi: 10.1016/j.jacc.2009.04.009.


The Development and Pathology working group was charged with reviewing the present knowledge, gaps in understanding, and areas for further studies in a broad range of themes. These themes in pulmonary vascular biology and pathobiology involved: 1) pulmonary vascular development; 2) pulmonary vascular disease accompanying fetal development and perinatal life; 3) properties of pulmonary vascular endothelial cells; 4) role of bone marrow cells in pulmonary vascular disease; 5) insights into pulmonary thromboembolic disease; 6) role of pathology in the assessment of pulmonary vascular disease; and 7) considerations of tissue banking for research in pulmonary hypertension. These important goals provide a blueprint for future research that may significantly impact our present and future understanding of pulmonary hypertension.

Publication types

  • Review

MeSH terms

  • Bone Marrow Cells / physiology
  • Endothelium, Vascular / pathology
  • Humans
  • Hypertension, Pulmonary / pathology*
  • Lung / embryology
  • Lung / pathology
  • Lung / physiopathology
  • Lung Diseases / pathology
  • Microcirculation / physiology
  • Neovascularization, Pathologic
  • Pulmonary Artery / embryology
  • Pulmonary Veins / embryology
  • Tissue Banks