Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe

Clin Perinatol. 2009 Jun;36(2):329-47, ix. doi: 10.1016/j.clp.2009.03.004.


Congenital diaphragmatic hernia (CDH) should be diagnosed in the prenatal period and prompt referral to a tertiary referral center for imaging, genetic testing, and multidisciplinary counseling. Individual prediction of prognosis is based on the absence of additional anomalies, lung size, and liver herniation. In severe cases, a prenatal endotracheal balloon procedure is currently being offered at specialized centers. Fetal intervention is now also offered to milder cases within a trial, hypothesizing that this may reduce the occurrence of bronchopulmonary dysplasia in survivors. Postnatal management has been standardized by European high-volume centers for the purpose of this and other trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diagnostic Imaging / methods*
  • Europe / epidemiology
  • Female
  • Fetal Diseases* / diagnosis
  • Fetal Diseases* / epidemiology
  • Fetal Diseases* / therapy
  • Hernia, Diaphragmatic* / diagnosis
  • Hernia, Diaphragmatic* / therapy
  • Hernias, Diaphragmatic, Congenital
  • Humans
  • Perinatal Care / trends*
  • Pregnancy
  • Prenatal Diagnosis / methods*
  • Prevalence