Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke

J Stroke Cerebrovasc Dis. Jul-Aug 2009;18(4):269-76. doi: 10.1016/j.jstrokecerebrovasdis.2008.11.009.


Background: Interleukin (IL)-1 receptor antagonist (RA) is an anti-inflammatory protein used to treat arthritis that has also been identified as a candidate stroke drug.

Methods: We conducted a systematic review and meta-analysis of reports of the efficacy of IL-1 RA in animal models of focal cerebral ischemia.

Results: We identified 16 published sources and one unpublished source of data. IL-1 RA reduced infarct volume by 38.2% (95% confidence interval 31.2%-45.1%). Efficacy was higher with higher doses, earlier treatment, and central administration of drug. No studies used animals with hypertension or diabetes or tested efficacy beyond 3 hours.

Conclusions: The animal data supporting IL-1 RA as a candidate drug for stroke are limited, and further experiments are required before proceeding to clinical trial.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / immunology
  • Brain / pathology
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / immunology
  • Brain Ischemia / physiopathology
  • Data Interpretation, Statistical
  • Disease Models, Animal
  • Drug Evaluation, Preclinical / methods
  • Interleukin 1 Receptor Antagonist Protein / antagonists & inhibitors*
  • Interleukin 1 Receptor Antagonist Protein / immunology
  • Interleukin-1 / antagonists & inhibitors*
  • Interleukin-1 / immunology
  • Reproducibility of Results
  • Stroke / drug therapy*
  • Stroke / immunology
  • Stroke / physiopathology
  • Treatment Outcome


  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1