Bisphosphonates and dental implants: current problems

Med Oral Patol Oral Cir Bucal. 2009 Jul 1;14(7):E355-60.


Osteonecrosis of the jaw has been described in patients taking bisphosphonates after oral surgery procedures, including the placement of dental implants. This review is an update of the relationship between bisphosphonates and dental implants. Results obtained by different authors are compared, contrasting earlier studies where an improvement in implant osseointegration using bisphosphonates was observed, with ones where statistically significant differences were found, and more recent studies disagreeing with the use of bisphosphonates for causing necrosis of the jaw. The differing results obtained between animal studies and the situation observed in humans may be due to a short medication and follow-up period, as well as to the existence of few research studies where dental implants are placed in the oral cavity. Currently, dental implants are contraindicated in patients being treated with intravenous bisphosphonates. In 2007, the American Association of Oral and Maxillofacial Surgeons suggested guidelines for patients treated with oral bisphosphonates, based on the clinical situation of the patient and the length of treatment with the drug, and that greater caution prior and subsequent to surgery should be taken for three years after treatment. All patients treated with bisphosphonates must have the risk of possible loss of implants and the risk of suffering a bony necrosis of the operated jaw explained to them, and give their informed consent prior to dental implant surgery.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Density Conservation Agents / adverse effects
  • Bone Density Conservation Agents / pharmacology*
  • Dental Implants*
  • Diphosphonates / adverse effects
  • Diphosphonates / pharmacology*
  • Humans
  • Jaw Diseases / chemically induced
  • Osseointegration / drug effects*
  • Osteonecrosis / chemically induced


  • Bone Density Conservation Agents
  • Dental Implants
  • Diphosphonates