Tight glycemic control and computerized decision-support systems: a systematic review

Intensive Care Med. 2009 Sep;35(9):1505-17. doi: 10.1007/s00134-009-1542-0. Epub 2009 Jun 27.


Objective: To identify and summarize characteristics of computerized decision-support systems (CDSS) for tight glycemic control (TGC) and to review their effects on the quality of the TGC process in critically ill patients.

Methods: We searched Medline (1950-2008) and included studies on critically ill adult patients that reported original data from a clinical trial or observational study with a main objective of evaluating a given TGC protocol with a CDSS.

Results: Seventeen articles met the inclusion criteria. Eleven out of seventeen studies evaluated the effect of a new TGC protocol that was introduced simultaneously with a CDSS implementation. Most of the reported CDSSs were stand-alone, were not integrated in any other clinical information systems and used the "passive" mode requiring the clinician to ask for advice. Different implementation sites, target users, and time of advice were used, depending on local circumstances. All controlled studies reported on at least one quality indicator of the blood glucose regulatory process that was improved by introducing the CDSS. Nine out of ten controlled studies either did not report on the number of hypoglycemia events (one study), or reported on no change (six studies) or even a reduction in this number (two studies).

Conclusions: While most studies evaluating the effect of CDSS on the quality of the TGC process found improvement when evaluated on the basis of the quality indicators used, it is impossible to define the exact success factors, because of simultaneous implementation of the CDSS with a new or modified TGC protocol and the hybrid solutions used to integrate the CDSS into the clinical workflow.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Blood Glucose / analysis
  • Critical Care
  • Decision Making, Computer-Assisted*
  • Decision Support Systems, Clinical*
  • Glycemic Index*
  • Humans


  • Blood Glucose