Quality of life in Serbian patients with Parkinson's disease

Qual Life Res. 2009 Sep;18(7):833-9. doi: 10.1007/s11136-009-9500-4. Epub 2009 Jun 27.


Background: The Parkinson's Disease Questionnaire (PDQ-39) is a well-validated British scale for the assessment of health-related quality of life (QoL) in Parkinson's disease (PD).

Objective: To validate the Serbian version of the PDQ-39, while also providing additional information on the characteristics of this instrument.

Patient and methods: A total of 102 Serbian PD patients were asked to complete the PDQ-39, a disease-specific QoL questionnaire, as well as the generic, health status questionnaire (SF-36-version 1), and the 21-item Beck Depression Inventory. Neurological examination included the Hoehn and Yahr staging, Unified Parkinson's disease rating scale (UPDRS)-part III, Schwab and England scale, and the Mini-Mental State Examination.

Results: Internal consistency analysis yielded a Cronbach's alpha of 0.83. Cronbach's alpha was above 0.70 for seven out of eight subscales (range from 0.73 to 0.91). A hierarchical structure of the PDQ-39 was revealed, with one global higher-order factor and two lower-order factors. The strongest predictor of the QoL in PD was the presence of depression, while motor disability (UPDRS-part III score) additionally contributed to poor QoL. Cognitive impairment has not been correlated with poor QoL. Also, QoL measures were not different between young- (< or =50 years) and older-onset PD patients.

Conclusions: The PDQ-39 is a reliable and valid instrument for the assessment of QoL in Serbian PD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Cognition Disorders / etiology
  • Depression / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / psychology*
  • Quality of Life
  • Serbia
  • Social Support