Thromboembolic events associated with Neuroform stent in endovascular treatment of intracranial aneurysms

J Neuroimaging. 2010 Apr;20(2):113-7. doi: 10.1111/j.1552-6569.2009.00390.x. Epub 2009 Jun 26.


Background: The incidence of thromboembolic events associated with Neuroform stent (Boston Scientific Target, Fremont, CA) is known from previous studies but there are uncertainties of scale.

Purpose: To report our rate of ischemic events associated with Neuroform stent.

Methods: Consecutive patients treated with Neuroform stent for intracranial aneurysms were prospectively enrolled from January 2003 to August 2006. Thromboembolic events as well as clinical outcomes were measured. Mean follow-up was 12 months.

Results: Successful stent deployment was achieved in (65/67) 97% of patients without any ischemic event. However, postoperative thromboembolic events were observed in 3 patients despite being on clopidogrel and aspirin. These 3 patients demonstrated poor platelet inhibitions in platelet aggregation (aggregometry) studies, and were successfully treated with intravenous eptifibatide with good outcome. The majority of the patients had good outcomes [Glasgow Outcome Score (GOS) 5 or National Institute of Health Stroke Scale (NIHSS) 0 in (63/67) 94%, GOS 4 or NIHSS 2 in 1 patient, and GOS 3 or NIHSS 4 was observed in 3 cases].

Conclusion: Our study reveals that the thromboembolic events associated with Neuroform stent may present in a delayed fashion. These events can be successfully treated with good outcome. Therefore, postoperative close follow-up is strongly recommended for all Neuroform stent-treated patients.

Publication types

  • Clinical Trial

MeSH terms

  • Blood Vessel Prosthesis / statistics & numerical data*
  • Comorbidity
  • Female
  • Humans
  • Incidence
  • Intracranial Aneurysm / epidemiology*
  • Intracranial Aneurysm / surgery*
  • Male
  • Middle Aged
  • New York / epidemiology
  • Risk Assessment
  • Risk Factors
  • Stents / statistics & numerical data*
  • Thromboembolism / epidemiology*
  • Thromboembolism / surgery*