Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system

Br J Pharmacol. 2009 Aug;157(7):1142-53. doi: 10.1111/j.1476-5381.2009.00337.x. Epub 2009 Jun 25.

Abstract

The purinergic system is composed of mononucleosides, mononucleoside polyphosphates and dinucleoside polyphosphates as agonists, as well as the respective purinergic receptors. Interest in the role of the purinergic system in cardiovascular physiology and pathophysiology is on the rise. This review focuses on the overall impact of dinucleoside polyphosphates in the purinergic system. Platelets, adrenal glands, endothelial cells, cardiomyocytes and tubular cells release dinucleoside polyphosphates. Plasma concentrations of dinucleoside polyphosphates are sufficient to cause direct vasoregulatory effects and to induce proliferative effects on vascular smooth muscle cells and mesangial cells. In addition, increased plasma concentrations of a dinucleoside polyphosphate were recently demonstrated in juvenile hypertensive patients. In conclusion, the current literature accentuates the strong physiological and pathophysiological impact of dinucleoside polyphosphates on the cardiovascular system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / chemistry
  • Antihypertensive Agents / therapeutic use
  • Cell Proliferation
  • Cystic Fibrosis / drug therapy
  • Dinucleoside Phosphates / chemistry
  • Dinucleoside Phosphates / physiology*
  • Dinucleoside Phosphates / therapeutic use
  • Eye Diseases / drug therapy
  • Fibrinolytic Agents / chemistry
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / physiology
  • Myocytes, Smooth Muscle / physiology
  • Protein Multimerization
  • Purinergic Agonists*
  • Receptors, Purinergic / chemistry
  • Respiratory Tract Diseases / drug therapy
  • Vasodilation / physiology

Substances

  • Antihypertensive Agents
  • Dinucleoside Phosphates
  • Fibrinolytic Agents
  • Purinergic Agonists
  • Receptors, Purinergic