Prevalence of Hepatitis C Virus Infection in Patients With COPD

Epidemiol Infect. 2010 Feb;138(2):167-73. doi: 10.1017/S0950268809990276. Epub 2009 Jun 29.

Abstract

Some studies have suggested that chronic hepatitis C virus (HCV) infection may induce an accelerated decline of forced expiratory volume in 1 second (FEV(1)). We performed a cross-sectional study to determine the prevalence of HCV infection in a sample of chronic obstructive pulmonary disease (COPD) patients and in a control group of blood donors. The clinical characteristics of HCV-positive and HCV-negative patients were compared. Anti-HCV antibody was determined and confirmed by HCV-RNA. The prevalence of HCV infection in COPD patients was 7.5% (95% CI 6.52-8.48) and in blood donors was 0.41% (95% CI 0.40-0.42). The HCV-positive patients had a lower FEV(1) (34.7 +/- 8.6%) and a higher BODE index (median = 6) than HCV-negative patients (42.7 +/- 16.5%, median = 4, respectively) (P = 0.011 and 0.027, respectively). Our results suggest a high prevalence of chronic HCV infection in patients with COPD in comparison with the blood donors. HCV-positive patients have a more severe disease.

MeSH terms

  • Aged
  • Antibodies, Viral / blood
  • Brazil / epidemiology
  • Cross-Sectional Studies
  • Hepacivirus / genetics
  • Hepacivirus / immunology
  • Hepacivirus / isolation & purification*
  • Hepatitis C / complications*
  • Hepatitis C / epidemiology*
  • Humans
  • Middle Aged
  • Prevalence
  • Pulmonary Disease, Chronic Obstructive / complications*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • RNA, Viral / blood
  • Respiratory Function Tests

Substances

  • Antibodies, Viral
  • RNA, Viral