The juxtamembrane region of EGFR takes center stage

Cell. 2009 Jun 26;137(7):1181-3. doi: 10.1016/j.cell.2009.06.008.


The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.

Publication types

  • Comment

MeSH terms

  • Cell Membrane / metabolism
  • Dimerization
  • ErbB Receptors / chemistry*
  • ErbB Receptors / metabolism*
  • Humans
  • Models, Molecular
  • Molecular Sequence Data


  • ErbB Receptors