Abstract
The incidence of immune-mediated anaphylaxis during anesthesia ranges from 1 in 10,000 to 1 in 20,000. Neuromuscular blocking agents represent the most frequently involved substances, followed by latex and antibiotics, but every drug or substance used may be involved. Diagnosis relies on tryptase measurements at the time of the reaction and skin tests and specific IgE or basophil activation assays.
MeSH terms
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Allergens / immunology
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Anaphylaxis
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Anesthesia, General
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Anti-Bacterial Agents / adverse effects
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Basophil Degranulation Test
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Drug Hypersensitivity / diagnosis
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Drug Hypersensitivity / epidemiology
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Drug Hypersensitivity / immunology*
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Drug Hypersensitivity / prevention & control
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Humans
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Hypersensitivity, Immediate / diagnosis
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Hypersensitivity, Immediate / epidemiology
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Hypersensitivity, Immediate / immunology*
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Hypersensitivity, Immediate / prevention & control
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Immunoglobulin E / blood
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Incidence
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Intraoperative Complications / immunology
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Intraoperative Complications / prevention & control
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Latex / immunology
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Latex Hypersensitivity / diagnosis
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Latex Hypersensitivity / epidemiology
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Latex Hypersensitivity / immunology*
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Latex Hypersensitivity / prevention & control
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Neuromuscular Blocking Agents / adverse effects
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Perioperative Care
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Tryptases / blood
Substances
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Allergens
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Anti-Bacterial Agents
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Latex
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Neuromuscular Blocking Agents
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Immunoglobulin E
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Tryptases