Familial incidence of C3 nephritic factor

Nephron. 1991;59(2):261-5. doi: 10.1159/000186562.

Abstract

C3 nephritic factor (NEF) has been found in 3 siblings presenting different (or none) degrees of renal disease. Other relatives, including their dead father, suffered from a renal illness. In 2 of the siblings, NEF activity was restricted to IgG1 and IgG3 subclasses. Familial NEF incidence and a shared C3 allotype and a common HLA haplotype including BfS alleles for the 3 NEF-positive siblings suggest that at least in our cases genetical factors may be involved in NEF generation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Complement C3 / analysis
  • Complement C3 / genetics
  • Complement C3 Nephritic Factor / analysis
  • Complement C3 Nephritic Factor / genetics*
  • Complement C4 / analysis
  • Female
  • Glomerulonephritis / blood
  • Glomerulonephritis / genetics*
  • Glomerulonephritis / immunology
  • HLA Antigens / analysis
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / classification
  • Male
  • Middle Aged
  • Phenotype

Substances

  • Complement C3
  • Complement C3 Nephritic Factor
  • Complement C4
  • HLA Antigens
  • Immunoglobulin G