[Acupuncture at points of the liver and gallbladder meridians for treatment of migraine: a multi-center randomized and controlled study]

Zhongguo Zhen Jiu. 2009 Apr;29(4):259-63.
[Article in Chinese]


Objective: To investigate the therapeutic effect and safety of acupuncture at points of The Liver and Gallbladder Meridians for treatment of migraine.

Methods: Multi-central, randomized and controlled trial was used and 253 cases of migraine were divided into an acupuncture group and a western medicine group. The acupuncture group was treated with acupuncture at points of The Liver and Gallbladder Channels with Taichong (LR 3), Yang-lingquan (GB 34), Fengchi (GB 20), Ququan (LR 8) selected as main points, and the western medicine group with oral administration of Flunarizine tablets for 4 therapeutic courses. The total therapeutic effects 3 and 6 months after the treatment, the scores of various symptoms of migraine before and after treatment, and the stability of therapeutic effect in one-year following-up survey were observed in the two groups.

Results: After treatment, mean times and duration of the headache attack were significantly improved in the two groups (all P < 0.01) with the acupuncture group better than the western medicine group (P < 0.05). The total effective rates for stopping pain after treatment, 3 months and 6 months after treatment in the acupuncture group were 93.0%, 93.0% and 87.7%, respectively, which were better than 85.6%, 86.5% and 69.2% in the western medication group (all P < 0.01). One year later, the stability of the therapeutic effect in the acupuncture group was better than that in the western medicine group (P < 0.05); the adverse reaction and the compliance in the acupuncture group were significantly superior to those in the western medicine group.

Conclusion: Acupuncture at points of The Liver and Gallbladder Meridians for treatment of migraine is safe, effective, and with stable long-term therapeutic effect.

Publication types

  • Comparative Study
  • English Abstract
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Acupuncture Points*
  • Acupuncture Therapy / methods*
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Female
  • Flunarizine / administration & dosage
  • Flunarizine / therapeutic use
  • Gallbladder / pathology
  • Headache / prevention & control
  • Histamine H1 Antagonists / administration & dosage
  • Histamine H1 Antagonists / therapeutic use
  • Humans
  • Liver / pathology
  • Male
  • Meridians
  • Middle Aged
  • Migraine Disorders / drug therapy
  • Migraine Disorders / pathology
  • Migraine Disorders / therapy*
  • Treatment Outcome
  • Young Adult


  • Histamine H1 Antagonists
  • Flunarizine