Risk of medically attended local reactions following diphtheria toxoid containing vaccines in adolescents and young adults: a Vaccine Safety Datalink study

Vaccine. 2009 Aug 6;27(36):4912-6. doi: 10.1016/j.vaccine.2009.06.038. Epub 2009 Jun 28.


Three vaccines currently recommended for adolescents (Tdap, Td, and MCV4 meningococcal conjugate vaccine) contain diphtheria toxoid. While the safety of individual diphtheria toxoid containing vaccines has been evaluated, less is known regarding the safety of administration of two or more of these vaccines, either concomitantly or sequentially. This study evaluated the risk of medically attended local reactions in adolescents and young adults with varying patterns of receipt of diphtheria toxoid containing vaccines. In general the risk of medically attended local reactions was low and did not differ with concomitant or sequential administration of diphtheria toxoid containing vaccines.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cohort Studies
  • Diphtheria Toxoid / adverse effects*
  • Diphtheria-Tetanus Vaccine / adverse effects*
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects*
  • Female
  • Humans
  • Male
  • Meningococcal Vaccines / adverse effects*
  • Vaccines, Conjugate / adverse effects
  • Young Adult


  • Diphtheria Toxoid
  • Diphtheria-Tetanus Vaccine
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Meningococcal Vaccines
  • Vaccines, Conjugate