Recurrence up to 3.5 years after antibiotic treatment of acute otitis media in very young Dutch children: survey of trial participants

Abstract

Objective: To determine the long term effects of antibiotic treatment for acute otitis media in young children.

Design: Prospective three year follow-up study within the framework of a primary care based, double blind, randomised, placebo controlled trial.

Setting: 53 general practices in the Netherlands.

Participants: 168 children aged 6 months to 2 years with acute otitis media.

Interventions: Amoxicillin 40 mg/kg/day in three doses compared with placebo.

Main outcome measures: Recurrence of acute otitis media; referral to secondary care; ear, nose, and throat surgery.

Results: Acute otitis media recurred in 63% (47/75) of children in the amoxicillin group and in 43% (37/86) of the placebo group (risk difference 20%, 95% confidence interval 5% to 35%); 30% (24/78 amoxicillin; 27/89 placebo) of children in both groups were referred to secondary care, and 21% (16/78) of the amoxicillin group compared with 30% (27/90) of the placebo group had ear, nose, and throat surgery (risk difference -9%, -23% to 4%).

Conclusion: Recurrent acute otitis media occurred more often in the children originally treated with amoxicillin. This is another argument for judicious use of antibiotics in children with acute otitis media. Trial registration Netherlands Trial Register NTR1426.