The small heat shock protein, HSPB6, in muscle function and disease

Cell Stress Chaperones. 2010 Jan;15(1):1-11. doi: 10.1007/s12192-009-0127-8. Epub 2009 Jul 1.


The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Asthma / metabolism
  • HSP20 Heat-Shock Proteins / metabolism
  • HSP20 Heat-Shock Proteins / physiology*
  • Humans
  • Hyperplasia / metabolism
  • Molecular Sequence Data
  • Muscle, Skeletal / metabolism
  • Muscle, Smooth / metabolism
  • Myocardium / metabolism
  • Phosphopeptides
  • Rats
  • Signal Transduction
  • Subarachnoid Hemorrhage / metabolism


  • HSP20 Heat-Shock Proteins
  • HSPB6 protein, human
  • Phosphopeptides