Identification of a novel human gammapapillomavirus species

J Gen Virol. 2009 Oct;90(Pt 10):2413-2417. doi: 10.1099/vir.0.012344-0. Epub 2009 Jul 1.


By using random PCR amplification, shotgun sequencing and sequence similarity searches, we analysed nucleic acids present in cell cultures inoculated with samples from unexplained cases of encephalitis. We identified a divergent human papillomavirus (HPV) sequence originating from a rectal swab. The full genome was amplified by inverse PCR and sequenced. The prototype of the sixth gammapapillomavirus species, HPV116, was not found in the patient's cerebrospinal fluid or respiratory secretions, nor in culture supernatants from other unexplained cases of encephalitis, indicating that its identification in an encephalitis patient was accidental.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Gammapapillomavirus / classification*
  • Gammapapillomavirus / genetics*
  • Genome, Viral
  • Humans
  • Macaca mulatta
  • Phylogeny
  • Polymerase Chain Reaction
  • Virus Diseases / genetics