Elite and stochastic models for induced pluripotent stem cell generation

Nature. 2009 Jul 2;460(7251):49-52. doi: 10.1038/nature08180.


Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cellular Reprogramming* / genetics
  • Epigenesis, Genetic
  • Humans
  • Mice
  • Models, Biological*
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism
  • Stochastic Processes
  • Transduction, Genetic