Abstract
Quick access: A concise and efficient formal synthesis of platencin has been accomplished in nine steps from a commercially available starting material. The synthesis utilized only one protecting group. The base-catalyzed Michael cyclization of precursor 1 afforded the key diketone 2, which was converted into the desired core structure 4 via the radical intermediate 3.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aminophenols / chemical synthesis*
-
Anti-Bacterial Agents / chemical synthesis*
-
Cyclization
-
Ketones / chemistry
-
Polycyclic Compounds / chemical synthesis*
-
Stereoisomerism
-
Streptomyces / chemistry*
Substances
-
Aminophenols
-
Anti-Bacterial Agents
-
Ketones
-
Polycyclic Compounds
-
platencin