Pancreatic cancer--could it be that simple? A different context of vulnerability

Cancer Cell. 2009 Jul 7;16(1):7-8. doi: 10.1016/j.ccr.2009.06.011.


In a recent issue of Science, Olive and colleagues document that inhibition of Hedgehog (Hh) signaling in a genetically engineered mouse model of pancreatic cancer can enhance the intratumor concentration of certain anticancer drugs. Could this finding provide us with a new method to attack pancreatic cancer?

MeSH terms

  • Hedgehog Proteins / physiology
  • Humans
  • Incidence
  • Magnetic Resonance Imaging
  • Pain
  • Pancreatic Neoplasms / epidemiology
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology*
  • Pancreatic Neoplasms / physiopathology
  • Perfusion Imaging
  • Survival Analysis
  • United States / epidemiology


  • Hedgehog Proteins