Structure and Signalling in the IL-17 Receptor Family

Nat Rev Immunol. 2009 Aug;9(8):556-67. doi: 10.1038/nri2586. Epub 2009 Jul 3.

Abstract

Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17 (T(H)17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease. IL-17A and its receptor (IL-17RA) are the founding members of a newly described family of cytokines and receptors that have unique structural features which distinguish them from other cytokine families. Research defining the signal transduction pathways induced by IL-17R family cytokines has lagged behind that of other cytokine families, but studies in the past 2 years have begun to delineate unusual functional motifs and new proximal signalling mediators used by the IL-17R family to mediate downstream events.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism*
  • Receptors, Interleukin-17 / immunology
  • Receptors, Interleukin-17 / metabolism*
  • Signal Transduction / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / metabolism

Substances

  • Cytokines
  • Interleukin-17
  • Receptors, Interleukin-17