Efficacy and safety of emodepside 2.1%/praziquantel 8.6% spot-on formulation in the treatment of feline aelurostrongylosis

Parasitol Res. 2009 Aug;105 Suppl 1:S83-9. doi: 10.1007/s00436-009-1499-5.

Abstract

The objective of the present study was to evaluate the efficacy and safety of the antiparasitic spot-on formulation containing emodepside 2.1%/praziquantel 8.6% (Profender, Bayer) in the treatment of natural feline infection with the lungworm Aelurostrongylus abstrusus (Nematoda, Strongylida). Efficacy of Profender given once at the licensed dose was tested in comparison to a control oral formulation containing fenbendazole 18.75% (Panacur, Intervet) given over three consecutive days at the licensed dose. Efficacy assessment was based on larvae per gramme of faeces (LPG) counts, measured on days 28 +/- 2 following treatment and compared to counts on days -6 to -2. In total 24 cats treated either with Profender (n = 12) or with Panacur (n = 12) were included in the assessment of efficacy and safety. Mean LPG post-baseline counts (days 28 +/- 2) were 1.3 LPG for both Profender and Panacur, demonstrating similar efficacy of 99.38% for Profender and 99.29% for the control product. No treated animals showed adverse events. This trial demonstrated that both Profender spot-on formulation and oral paste Panacur are safe and effective in the treatment of aelurotrongylosis in cats. Future practical perspectives in feline medicine and the major advantages of the spot-on product compared to the oral paste are discussed.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / administration & dosage
  • Anthelmintics / adverse effects
  • Anthelmintics / therapeutic use*
  • Cat Diseases / drug therapy*
  • Cat Diseases / parasitology
  • Cats
  • Depsipeptides / administration & dosage
  • Depsipeptides / adverse effects
  • Depsipeptides / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Feces / parasitology
  • Fenbendazole / administration & dosage
  • Fenbendazole / adverse effects
  • Fenbendazole / therapeutic use
  • Larva / drug effects
  • Metastrongyloidea / drug effects
  • Metastrongyloidea / isolation & purification
  • Praziquantel / administration & dosage
  • Praziquantel / adverse effects
  • Praziquantel / therapeutic use*
  • Strongylida Infections / drug therapy
  • Strongylida Infections / parasitology
  • Strongylida Infections / veterinary*
  • Treatment Outcome

Substances

  • Anthelmintics
  • Depsipeptides
  • Drug Combinations
  • Fenbendazole
  • Praziquantel
  • emodepside